• CDK S phosphorylation status influences the

  2019-08-20

  

  CDK5-S47 phosphorylation status influences the differential cellular proliferation versus migration response: Previous work from our laboratory has shown CDK5 to be a critical determinant of the cellular proliferation-migration dichotomy whereby CDK5 activation downstream of stimulated epidermal gro

• ERR is present early in the

  2019-08-20

  

  ERRβ is present early in the developing placenta in a subset of rsv virus in extra-embryonic ectoderm destined to make up the chorion.19, 20 ERRβ is likely essential for reproduction. ERRβ expression is essential for the maintenance of pluripotency and self-renewal potential in mouse embryonic stem

• br Signaling of DDR receptor and its regulation Being the

  2019-08-20

  

  Signaling of DDR2 receptor and its regulation Being the tyrosine kinase receptor, downstream signaling of DDR2 receptor is initiated by phosphorylation of cytoplasmic tyrosine residue upon ligand binding (Type II collagen) but the authentic facts or detail information of tyrosine phosphorylation

• POM 1 br Results br Discussion Mucosal barriers

  2019-08-20

  

  Results Discussion Mucosal barriers are constitutively challenged by various stimuli, and the homeostasis of mucosal barriers both at steady state and upon challenge are maintained by tissue-resident immune POM 1 (Kurashima et al., 2013, Okumura and Takeda, 2016). ILC3s are found in lymphoid

• TRAF and TRAF were initially identified as

  2019-08-20

  

  TRAF1 and TRAF2 were initially identified as tumor necrosis factor receptor 2 (TNRF2)-associated components, TRAF4 was overexpressed in breast carcinoma cells, whereas TRAF3, TRAF5 and TRAF6 were discovered by their interaction with specific domains in the cytoplasmic tails of trans-membrane recepto

• br Conclusions br ISG is an ubiquitin like protein that

  2019-08-20

  

  Conclusions ISG15 is an ubiquitin‐like protein that is induced by treating mammalian Swainsonine with interferon‐α/β. UbE1L was identified as the E1‐activating enzyme for ISG15 in the course of experiments that demonstrated that the nonstructural or NS1 protein of influenza B virus inhibits IS

• Contrary to genetic aberrations epigenetic methylation marke

  2019-08-20

  

  Contrary to genetic aberrations epigenetic methylation markers with broad coverage of OvCa subtypes were detected in primary tumors [21]. Ibanez de Caceres et al. [22] identified hypermethylation of BRCA1, APC, p16, p14, DAPK or RASSF1A in 50 of 50 primary tumors. Moreover the methylation pattern wa

• br Acknowledgments We are thankful to the University of

  2019-08-19

  

  Acknowledgments We are thankful to the University of Guilan Research Council for partial support of this work. Introduction It is significant to predict the mass, number and velocity distribution of BAD generated by RHA subjected to penetration of EFP by the thickness of target and the impact

• Our previous high throughput screening

  2019-08-19

  

  Our previous high-throughput screening (HTS) campaign using automated, robust, and sensitive fluorescence based Caspase-8 Fluorometric Assay Kit assay [10], [11] led to the identification of several EPAC specific inhibitors (ESIs), and was subsequently followed by extensive hit-to-lead optimization

• Interestingly anti inflammatory actions for sPLA

  2019-08-19

  

  Interestingly, anti-inflammatory actions for sPLA2-V were also described in mice a few years ago in a model of autoimmune complex mediated arthritis [148]. A novel mechanism was delineated, whereby sPLA2-V promotes phagocytosis of immune complexes by macrophages to ameliorate inflammation in autoimm

• br Results and discussion The effects of hypoxia a

  2019-08-19

  

  Results and discussion The effects of hypoxia, a combination of shear stress and hyperoxia, and a combination of shear stress and hypoxia in BAECs were assessed at 0, 15, 30, 60, 120, and 180 min. Changes in phosphorylation levels of eNOS at Ser635 were investigated using immunoblotting, and repr

• p-gp inhibitors list Materials and methods br Results Assay

  2019-08-19

  

  Materials and methods Results Assay of botulinum toxin activity is critical for the risk-assessment, diagnosis, and treatment of botulism cases. The frequently encountered active forms of the toxin are; L chain (inside intoxicated neuronal cells), BoNT (in the blood stream of a botulism patient,

• The generation of ROS in addition to

  2019-08-19

  

  The generation of ROS, in addition to eliciting oxidative stress, is an important proapoptotic signal (Ott et al., 2007). Apoptosis is clearly associated with the production of ROS, since ROS generation occurs in the mitochondrial respiratory chain and disturbs mitochondrial homeostasis, which plays

• integrin inhibitor br Development of the double strand break

  2019-08-19

  

  Development of the double strand break repair model for meiotic recombination Meiotic recombination was first described by Frans Alfons Janssens using integrin inhibitor in the salamander Batracoseps attenuatus in 1909 [21] and then further elaborated at the genetic level in Drosophila by Thomas

• br Materials and methods br Results br

  2019-08-19

  

  Materials and methods Results Discussion In this work, we have studied the contribution of different pathways to the slow but stable progression of replication forks through DNA damaged by MMS [15]. The in vivo analysis of DNA replication forks along a specific chromosome of S. cerevisiae h

15437 records 940/1030 page Previous Next First page 上5页 936937938939940 下5页 Last page