• Cell Cycle Compound Library In this study we examined the ro

  2018-11-05

  

  In this study, we examined the role of ADAM17 in colitis by developing dextran sulfate sodium (DSS)-induced colitis using two different conditional Adam17-deficient mice, i.e. mice with systemic deletion by the inducible Mx1-Cre gene of Adam17 (Adam17Mx1-Cre+) or those with its deletion in myeloid C

• Today recent technological advances have dramatically improv

  2018-11-05

  

  Today, recent technological advances have dramatically improved the prospect of applying broadly the concept of precision medicine. Large-scale databases, omics technologies, cellular assays, epigenetics, informatics as well as imaging technologies converge towards optimum disease prevention, diagno

• cycloastragenol Of note is that a minimal improvement both

  2018-11-05

  

  Of note is that a minimal improvement, both in cognitive and neuroanatomical measures, was demonstrated in the OSA patients randomized to BSC over one month (Table 2, Supplementary Table S3). Similar improvement in patients with OSA has been previously associated with the improved sleep quality and

• Androgen signaling is central to prostate cancer

  2018-11-05

  

  Androgen signaling is central to prostate cancer development and progression. A milestone in progression of advanced prostate cancer when it transitions from endocrine-driven to paracrine- or intracrine-driven androgen signaling, with progressive complexities in steroid hormone biosynthesis and alt

• histone acetyltransferase What is the functional significanc

  2018-11-05

  

  What is the functional significance of VPS35/retromer-turning off PTH1R signaling? The increased and sustained PTH(1–34) signaling in Vps35-deficient OB-lineage histone acetyltransferase corroborates well with the impaired PTH(1–34)-driven catabolic response (e.g., RANKL/OPG-expression and OC genes

• Regions of linkage disequilibrium LD were defined for

  2018-11-05

  

  Regions of linkage disequilibrium (LD) were defined for the three loci tagged by SNPs reaching genome-wide significance. rs17599026, associated with urinary frequency, tags a 106kb region of LD (base position 137,657,783–137,763,798; Fig. 2A) containing part of KDM3B (including the promoter region t

• Lung cancer is the most common cancer in US

  2018-11-05

  

  Lung cancer is the most common cancer in US and worldwide (Centers for Disease Control and Prevention and National Center for Health Statistics, 2013; American Cancer Society, 2014), and the survival rate is low (Howlader et al., 2013). Most cases (90%) of lung cancer are attributable to smoking (Ge

• br Conflicts of Interest br Author Contributions J Jian

  2018-11-05

  

  Conflicts of Interest Author Contributions J. Jian designed and performed experiments, collected and analyzed data, and wrote the paper. Q.Y. Tian, S. Zhao, H. Liu, and Y. Zhao performed experiments, collected and analyzed data. W. Chen, and G. Grunig established the chronic lung inflammation

• br In the past thirty years we have seen dramatic

  2018-11-05

  

  In the past thirty years we have seen dramatic advances in vaccine technology and development that have yielded vaccines to protect against the pneumococcus, Hib, rotavirus, HPV, and meningococcal disease amongst others (). We have also seen a paradigm shift in the availability of these vaccines i

• Assuming that quantification of total Tregs using

  2018-11-05

  

  Assuming that quantification of total Tregs using demethylation of the FOXP3 gene or flow cytometry are correlates of true Tregs, these studies suggest that circulating Tregs may not be a strong predictor of myocardial infarction that could translate into a usable predictor in the clinic. The studie

• bcrp inhibitor The complex interplay between viral

  2018-11-05

  

  The complex interplay between viral escape and Env conformation observed by Bradley et al. and others gives some pause to reductionist approaches focussing on recapitulating single bNAb specificities by immunisation. Favourable bcrp inhibitor interactions between different bNAb epitopes, shown here

• br Approximately years ago new flavivirus was discovered in

  2018-11-05

  

  Approximately 70years ago, new flavivirus was discovered in the Zika forest of Uganda (). The eponymous virus is an arthropod-borne human pathogen that caused infrequent infections with relatively mild illness in Africa and received relatively little attention until recently. Over the last several

• Self rated health SRH is a

  2018-11-05

  

  Self-rated health (SRH) is a subjective perception and has become an increasingly common measure for public health monitoring. SRH is a strong independent predictor of mortality after accounting for objective health status, behavioral risk factors and socio-demographic characteristics, and it also p

• Since the creation of in it

  2018-11-05

  

  Since the creation of , in 2008, it has never been a year as exciting as 2014. Over the past year, we accomplished two of the main goals of the editorial board: indexation in an international database (Scopus), including the indexation of our entire previous archive, and the management by a major sc

• About a third of epileptic patients present seizures during

  2018-11-05

  

  About a third of epileptic patients present seizures during sleep [51]. Sleep can activate the occurrence of seizures and electroencephalogram (EEG) abnormalities [52]. Van Golde refers that during NREM (non-rapid eye movement) sleep discharges are facilitated (most likely for the synchronized patte

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