• The tight regulation of its dosage and allelic expression

  2018-11-09

  

  The tight regulation of its dosage and allelic expression led us hypothesize that Igf2 has a very precise function in stem cells: early in development, Igf2 would ensure the adequate expansion of stem H-Lys(Ac)-OH.HCl Supplier present in developing organs, then during post-natal life, Igf2 would c

• The most well studied angiogenic factor that is regulated

  2018-11-08

  

  The most well-studied angiogenic factor that is regulated by hypoxia is VEGF; hypoxic induction of an HIF-1-dependent bFGF autocrine loop drives angiogenesis, over-expression of Ang-1 causes a significant increase in HIF-1 stabilization and PDGF-BB participates in an autocrine-paracrine survival pat

• The Rad protein is a key

  2018-11-08

  

  The Rad51 protein is a key player in DNA double-strand break (DSB) repair by homologous recombination (HR). The expression level of Rad51 typically varies throughout the cell cycle, with the lowest expression found in the G1 phase, increasing throughout S-phase, and peaking in G2/M (Chen et al., 199

• Main Text One promise of IPSC

  2018-11-08

  

  Main Text One promise of IPSC-based cell therapy is that personalized medicine using cells from the patient may be feasible. Somatic cells could be harvested and reprogrammed with integration-free methods to produce a stock of clinically compliant pluripotent cells ready for use at any time in late

• A number of reports have

  2018-11-08

  

  A number of reports have demonstrated that pluripotent ESCs can form embryoid bodies (EBs) and spontaneously differentiate into PGCs and haploid spermatids in vitro (Geijsen et al., 2004; Hayashi et al., 2011; Kee et al., 2009; Toyooka et al., 2003), thereby providing an alternative model to investi

• Whereas continuous exposure to all three factors resulted in

  2018-11-08

  

  Whereas continuous exposure to all three factors (4+) resulted in higher levels of DE genes, there was no significant difference in the proportion of Foxa2+Sox17+ dhpg when compared to transient Wnt activation (2+2−). Surprisingly, T expression in a fraction of differentiated cells was detected in

• apomorphine br H AZ lysine methylation The lysine methyltran

  2018-11-08

  

  H2AZ lysine methylation The lysine methyltransferases SETD6 and SET7 efficiently methylate H2AZ in vitro (Binda et al., 2013). In particular, a detailed study clearly identified lysine 7 as the preferred site of methylation by SETD6 on H2AZ. This result was confirmed by mass spectrometric analysi

• The goals of this study were to evaluate

  2018-11-08

  

  The goals of this study were to evaluate if human fetal gallbladder contains a clonogenic candidate stem cell population and compare its phenotypic and expression profiles to those of fetal IHBD cells. The evaluation of human fetal gallbladder stem Digoxigenin-11-dUTP would have important ramificati

• br Resource details To generate the human iPSC line N

  2018-11-08

  

  Resource details To generate the human iPSC line, N44SV.5, non-integrative Sendai viruses containing the reprogramming factors Oct3/4, Sox2, cMyc, Klf4 have been employed (Takahashi et al., 2007). For this purpose, commercially available fibroblasts from a healthy juvenile donor were acquired in

• Using similar approach additional mESC lines could be derive

  2018-11-08

  

  Using similar approach, additional mESC lines could be derived using a Pitx3::GFP reporter mouse (Zhao et al., 2004) and another aSYN mouse model of Parkinson\'s disease, expressing human WT SNCA (Westerlund et al., 2008) (data now shown). These mESC lines (Table 1) can be used to study human SNCA-

• br Experimental Procedures br Acknowledgments We

  2018-11-08

  

  Experimental Procedures Acknowledgments We thank A. Voigt, N. Perrimon, S.X. Hou, X. Zeng, H. Sun, G.H. Beag, and X. Yang for reagents; the Iowa Developmental Studies Hybridoma Bank for antibodies; the Bloomington Stock Center and Drosophila Genetic Resource Center for Drosophila stocks; J.M.

• guanylate cyclase Our studies show that only a subpopulatio

  2018-11-08

  

  Our studies show that only a subpopulation of hESCs at the top of the hierarchy possesses an extensive capacity for self-renewal. Polanco et al. recently showed that guanylate cyclase in this compartment could reestablish the continuum of cell states seen in unfractionated cultures (Polanco et al.

• Prolonged APs and EADs are typical of pharmacologically indu

  2018-11-08

  

  Prolonged APs and EADs are typical of pharmacologically induced LQTS modeled in nonhuman hearts (Shimizu and Antzelevitch, 2000; Studenik et al., 2001; Terentyev et al., 2014), yet few such studies examined [Ca2+]i transients. The lengthening of APs and [Ca2+]i transients after pharmacologically blo

• The WNT signaling pathway is a

  2018-11-08

  

  The WNT signaling pathway is a primary determinant in assigning an A/P positional identity to NPCs. This instructional cue is imparted early during NPC generation and once this identity is established, it is stable and cannot be altered through exogenous manipulation of the WNT pathway. Using a WNT

• Despite the potential for tissue specific accumulation of

  2018-11-08

  

  Despite the potential for tissue specific accumulation of dysfunctional mitochondria, MRT understandably is of considerable appeal to couples coping with a devastating mitochondrial disease as such intervention provides the only hope for a healthy child. Depending on the tissues and proportion of di

15437 records 1011/1030 page Previous Next First page 上5页 10111012101310141015 下5页 Last page